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Genomic dissection of inbreeding depression: a gate to new opportunities R. Bras. Zootec.
Curik,Ino; Ferenčaković,Maja; Sölkner,Johann.
ABSTRACT Inbreeding depression, reduction in performance of quantitative traits, including reproduction and survival, caused by inbreeding, is a well-known phenomenon observed in almost all experimental, domesticated, and natural populations. In spite of its importance to the fate of a small population and numerous research performed in the last century, the genetic basis of inbreeding depression is still unclear. Recent fast development of molecular techniques has enabled estimation of a genomic inbreeding coefficient (FROH), which reflects realized autozygosity and can be further partitioned to chromosomes and chromosomal segments. In this review, we first describe classical approach used in the estimation of inbreeding in livestock populations, followed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Autozygosity; Detrimental load; Genomics; Runs of homozygosity.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982017000900773
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